分子生物学文章求翻译NIPP1isaubiquitousnu-查字典问答网
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  分子生物学文章求翻译NIPP1isaubiquitousnuclearproteinthatisrequiredforspliceosomeassembly.Wereportherethatthephos-phothreonine-bindingForkhead-associateddomainofNIPP1interactswiththecellcycle-regulatedproteinSer/Thr

  分子生物学文章求翻译

  NIPP1isaubiquitousnuclearproteinthatisrequired

  forspliceosomeassembly.Wereportherethatthephos-

  phothreonine-bindingForkhead-associateddomainof

  NIPP1interactswiththecellcycle-regulatedprotein

  Ser/ThrkinaseMELK(maternalembryonicleucinezip-

  perkinase).TheNIPP1-MELKinteractionwascritically

  dependentonthephosphorylatonofThr-478ofMELK

  andwasincreasedinlysatesfrommitoticallyarrested

  cells.RecombinantMELKwasapotentinhibitorofan

  earlystepofspliceosomeassemblyinnuclearextracts.

  Thissplicingdefectwasalsoseenwithakinase-dead

  mutantbutwasabsentaftermutation(T478A)ofthe

  NIPP1bindingsiteofMELK,indicatingamediatory

  roleforNIPP1.OurdatasuggestthatMELKhasarolein

  thecellcycle-regulatedcontrolofpre-mRNAsplicing.

1回答
2019-05-04 07:27
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侯锡九

  NIPP1是一种普遍存在于细胞核中的蛋白,它在剪接体的装配中必须是的.在这里,我们报道NIPP1中与磷酸化苏氨酸结合的forkhead相关结构域和细胞周期调控蛋白——Ser/Thr激酶MELK之间的相互作用.NIPP1与MELK之间的作用严格...

2019-05-04 07:30:06

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