求高手翻一下英文药学论文摘要,看不懂晕死了.1Arapidandsensitivemethod,basedonliquidchromatography,hasbeendevelopedfordeterminationofmetoclopramideconcentrationsinplasmaandurinesamples.Concentrationsdownto15nm
求高手翻一下英文药学论文摘要,看不懂晕死了.
1Arapidandsensitivemethod,basedonliquidchromatography,hasbeendevelopedfordeterminationofmetoclopramideconcentrationsinplasmaandurinesamples.Concentrationsdownto15nmol/1(5ng/ml)ofplasmaand100nmol/1(30ng/ml)ofurinecouldbedeterminedwitharelativestandarddeviationoflessthanorequalto10%.Themethodwasusedtostudydispositionofmetoclopramideinhealthyvolunteersfollowingsingledosesintravenouslyandorallyasaqueoussolutionandaslowreleasetablet.2Theinitialdistributionafterintravenousadministrationwasveryrapid.Theeliminationhalf-lifepostdistributionwas4.9h.Theapparentvolumeofdistribution,Vd,was3.01/kgbodyweight.Onaverage19%wasexcretedunchangedafterintravenousadministrationof5and10mg(15and30mumol)ofdrug.Therateofabsorptionofmetoclopramidewasdelayedafteradministrationofaslowreleasetabletandthemaximumplasmaconcentrationwasabout50%lowerthanafterasolution.Theextentofbioavailabilitywasthesamefollowingthetwodifferentformulationssuggestingafirst-passeliminationof25-40%